Search
RANTES; C-C motif chemokine 5; EoCP; eosinophil chemotactic cytokine; SIS-delta; small-inducible cytokine A5; T cell-specific protein P228; TCP228; T cell-specific protein RANTES (CCL5, D17S136E, SCYA5)
Function:
- chemoattractant for blood monocytes, memory T-helper cells & eosinophils
- causes release of histamine from basophils & activates eosinophils
- binds to CCR1, CCR3, CCR4 & CCR5
- one of the major HIV-suppressive factors produced by CD8+ T-cells
- recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, & simian immunodeficiency virus (SIV)
- the processed form RANTES(3-68) acts as a natural chemotaxis inhibitor & is a more potent inhibitor of HIV-1-infection
- the second processed form RANTES(4-68) exhibits reduced chemotactic & HIV-suppressive activity compared with RANTES(1-68) & RANTES(3-68) & is generated by an unidentified enzyme associated with monocytes & neutrophils
- N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes & cultured sarcoma cells
Structure:
- O-linked oligosaccharides at Ser-27 & Ser-28
- belongs to the intercrine beta (chemokine CC) family
Compartment: secreted
Expression:
- T-cell & macrophage specific
- induced by mitogens
Polymorphism:
- variant Phe-24 is an antagonist of the chemokine receptors CCR1 & CCR3
Interactions
molecular events
General
CC chemokine; beta chemokine
glycoprotein
sis family protein
Properties
SIZE: entity length = 91 aa
MW = 10 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
proteolytic site {25-26}
Ser glycosylation site {S27}
Ser glycosylation site {S28}
cysteine residue {C33}
MODIFICATION: cysteine residue {C57}
cysteine residue {C34}
MODIFICATION: cysteine residue {C73}
cysteine residue {C57}
MODIFICATION: cysteine residue {C33}
cysteine residue {C73}
MODIFICATION: cysteine residue {C34}
methionine residue {90}
SECRETED-BY: T-cell
References
- UniProt :accession P13501
- NIEHS-SNPs
http://egp.gs.washington.edu/data/ccl5/
- Wikipedia; Note: RANTES entry
http://en.wikipedia.org/wiki/RANTES
Databases & Figures
OMIM 187011
UniProt P13501
Pfam PF00048
Entrez Gene 6352
Kegg hsa:6352
CC ligand and receptor binding