ran GTPase-activating protein1 (ranGAP1)

Function: - GAP activity specific for ran protein - sumoylated by SUMO1 - sumoylation leads to association of - RanGAP1 with the nuclear envelope (NE) (putative) Structure: - homodimer - forms a tight complex in association with RANBP2 & the ubiquitin-conjugating enzyme E2 (UBC9) - belongs to the RNA1 family - contains 6 LRR repeats (leucine-rich repeats) Compartment: cytoplasm Expression: - highly expressed in brain, thymus & testis

General

GTPase-activating protein (GAP) phosphoprotein

Properties

SIZE: entity length = 587 aa MW = 64 kD COMPARTMENT: cytoplasm MOTIF: leucine-rich repeat SITE: 48-71 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 111-134 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 207-230 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 235-258 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 292-319 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 320-343 MOTIF: leucine residue (SEVERAL) acidic region {359-397} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S428} Ser phosphorylation site {S442}

Database Correlations

OMIM 602362 UniProt P46060

References

UniProt :accession P46060