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Ran-binding protein 10 (RanBP10, RANBP10, KIAA1464)
Function:
- may act as an adapter protein to couple membrane receptors to intracellular signaling pathways
- in contrast to RANBP9, does not interact with Sos & does not activate the Ras pathway
- interacts with RAN
- interacts with the HGF receptor MET
Structure:
- SPRY domain mediates the interaction with MET
- belongs to the RANBP9/10 family
- contains 1 B30.2/SPRY domain
- contains 1 CTLH domain
- contains 1 LisH domain
Expression:
- broadly expressed, with highest levels in skeletal muscle
General
phosphoprotein
Properties
SIZE: entity length = 620 aa
MW = 67 kD
MOTIF: B30.2/SPRY {35-222}
LisH {253-285}
CTLH {291-348}
serine-rich region {346-453}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S365}
Ser phosphorylation site {S369}
Database Correlations
UniProt Q6VN20
Pfam PF00622
References
UniProt :accession Q6VN20