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raf proto-oncogene protein or mil proto-oncogene protein
Structure:
- said to lack SH2 domain despite binding to & being activated by tyrosine kinases
Interactions
molecular events
Specific
raf1 proto-oncogene protein
serine/threonine protein kinase A-Raf; proto-oncogene A-Raf; proto-oncogene A-Raf-1; proto-oncogene Pks (ARAF, ARAF1, PKS, PKS2)
serine/threonine protein kinase B-raf; proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1 (BRAF BRAF1 RAFB1)
General
proto oncogene protein
serine/threonine kinase
Properties
COMPARTMENT: cytoplasm
MOTIF: DAG/PE-binding domain {N-TERMINAL}
MOTIF: binding site
FOR-BINDING-OF: diacylglycerol
Zinc finger
NAME: Zinc finger (2)
EFFECTOR-BOUND: Zn+2
binding site
FOR-BINDING-OF: ras subfamily protein
domain
MOTIF: serine residue (SEVERAL)
threonine residue (SEVERAL)
HOMOLOGY: raf proto-oncogene protein*
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Ser phosphorylation site
STATE: active state
References
- Cantley LC, Auger KR, Carpenter C, Duckworth B,
Graziani A, Kapeller R, Soltoff S.
Oncogenes and signal transduction.
Cell. 1991 Jan 25;64(2):281-302. Review.
Erratum in: Cell 1991 May 31;65(5):following 914.
PMID: 1846320
- Vojtek AB, Hollenberg SM, Cooper JA.
Mammalian Ras interacts directly with the serine/threonine
kinase Raf.
Cell. 1993 Jul 16;74(1):205-14.
PMID: 8334704