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cell cycle checkpoint control protein RAD9A; hRAD9; DNA repair exonuclease rad9 homolog A (RAD9A)
Function:
1) component of the 9-1-1 cell-cycle checkpoint response complex
2) 3'->5' double stranded DNA exonuclease activity
- exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
3) constitutively phosphorylated on Ser & Thr in absence of DNA damage
4) hyperphosphorylated by PRKCD & ABL1 upon DNA damage
5) phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex
6) interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, RPA2
7) interacts with DNAJC7 & RHNO1
Compartment: nucleus
General
exodeoxyribonuclease
phosphoprotein
Properties
SIZE: MW = 43 kD
entity length = 391 aa
COMPARTMENT: cell nucleus
MOTIF: Tyr phosphorylation site {Y28}
active site
SITE: 51-91
Sufficient for interaction with ABL1. {266-391}
MOTIF: Ser phosphorylation site {S272}
Ser phosphorylation site {S277}
Ser phosphorylation site {S328}
Ser phosphorylation site {S341}
Ser phosphorylation site {S375}
Ser phosphorylation site {S380}
Ser phosphorylation site {S387}
Database Correlations
OMIM 603761
UniProt Q99638
Pfam PF04139
Entrez Gene 5883
Kegg hsa:5883
ENZYME 3.1.11.2
References
- UniProt :accession Q99638
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad9a/
Component-of
9-1-1 cell-cycle checkpoint response complex