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DNA repair protein RAD51 homolog 3; R51H3; RAD51-like protein 2 (RAD51C RAD51L2)
Function:
- role in homologous recombination repair pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents
- the RAD51B-RAD51C dimer exhibits single-stranded DNA dependent ATPase activity
- component of the BCDX2 complex
- interacts with RAD51B & XRCC3
- part of a complex with RAD51B & RAD51
Structure: belongs to the recA family, RAD51 subfamily
Compartment: nucleus (probable)
Expression:
- expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen & prostate
General
DNA repair protein Rad51 homolog
Properties
SIZE: entity length = 376 aa
MW = 42 kD
COMPARTMENT: cell nucleus
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 125-132
References
- UniProt :accession O43502
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad51c/
Component-of
BCDX2 complex
Databases & Figures
OMIM 602774
UniProt O43502
Pfam PF08423
Entrez Gene 5889
Double strand break repair: homologous recombination