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DNA repair protein RAD51 homolog 1; hRAD51; HsRAD51 (RAD51, RAD51A, RECA)
Function:
- role in a common DNA damage response pathway associated with activation of homologous recombination & double-strand break repair
- binds to single-stranded DNA & double-stranded DNA & exhibits DNA-dependent ATPase activity
- unwinds duplex DNA & forms helical nucleoprotein filaments
- phosphorylated
- phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage & promote DNA repair by homologous recombination
- interacts with BRCA1, BRCA2 & either directly or indirectly with p53
- interacts with XRCC3, RAD54L & RAD54B
- part of a complex with RAD51C & RAD51B
- interacts with RAD51AP1 & RAD51AP2
- interacts with CHEK1/CHK1; this may require prior phosphorylation of CHEK1
- interacts with the MND1-PSMC3IP
- heterodimer (putative)
- interacts with OBFC2B
- appears to be involved in surveillance of chromosomes for double-strand breaks
Structure:
- belongs to the recA family, RAD51 subfamily
- contains 1 HhH domain
Compartment:
- nucleus
- colocalizes with RAD51AP1 to multiple nuclear foci upon induction of DNA damage
Alternative splicing: named isoforms=2
Expression:
- highly expressed in testis & thymus > small intestine, placenta, colon, pancreas & ovary > breast
Pathology:
- defects in RAD51 are associated with breast cancer
Interactions
molecular events
General
DNA repair protein Rad51 homolog
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 339 aa
MW = 37 kD
COMPARTMENT: cell nucleus
MOTIF: HhH {48-77}
ATP-binding site
NAME: ATP-binding site
SITE: 127-134
Thr phosphorylation site {T309}
References
- UniProt :accession Q06609
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad51/
Component-of
molecular complex
Databases & Figures
OMIM correlations
UniProt Q06609
Pfam PF08423
Entrez Gene 5888
Kegg hsa:5888
Figures/diagrams/slides/tables related to DNA repair protein RAD51 homolog 1