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UV excision repair protein RAD23 homolog B; HR23B; hHR23B; XP-C repair-complementing complex 58 kD protein; p58 (RAD23B)
Function:
- plays a central role both in proteosomal degradation of misfolded proteins & DNA repair.
- central component of a complex required to couple deglycosylation & proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol
- involved in DNA excision repair by stabilizing XPC protein
- may play a part in DNA damage recognition &/or in altering chromatin structure to allow access by damage-processing enzymes
- component of a complex required to couple retrotranslocation, ubiquitination & deglycosylation composed of NGLY1, SAKS1, AMFR, VCP & RAD23B (putative)
- interacts with the 26S proteasome
- interacts directly with NGLY1
- heterodimer of a 125 kD subunit (p125) & of a 58 kD subunit (p58)
- interacts with MJD & XPC
Structure:
- the ubiquitin-like domain mediates interaction with MJD
- belongs to the RAD23 family
- contains 1 STI1 domain
- contains 2 UBA domains
- contains 1 ubiquitin-like domain
Compartment: nucleus. cytoplasm (putative)
General
phosphoprotein
rad23 homolog
Properties
SIZE: entity length = 409 aa
MW = 43 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ubiquitin-like {1-79}
threonine-rich region {103-106}
MOTIF: threonine residue (SEVERAL)
Thr phosphorylation site {T155}
Ser phosphorylation site {S160}
UBA 1 {188-228}
alanine-rich region {254-260}
MOTIF: alanine residue (SEVERAL)
threonine-rich region {261-269}
MOTIF: threonine residue (SEVERAL)
STI1 {274-317}
glycine-rich region {336-348}
UBA 2 {364-404}
Database Correlations
OMIM 600062
UniProt P54727
PFAM correlations
Entrez Gene 5887
Kegg hsa:5887
References
- UniProt :accession P54727
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad23b/
- de Laat WL et al,
Molecular mechanisms of nucleotide excision repair.
Genes & Dev 13:768-85, 1999
PMID: 10197977
- Entrez Gene :accession 5887
Component-of
NGLY1-SAKS1-AMFR-VCP-RAD23B complex