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UV excision repair protein RAD23 homolog A; HR23A; hHR23A (RAD23A)
Function:
- role in postreplication repair of UV-damaged DNA
- postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with MJD
- interacts with HIV-1 Vpr
Structure:
- the ubiquitin-like domain mediates interaction with MJD
- belongs to the RAD23 family
- contains 2 UBA domains
- contains 1 ubiquitin-like domain
Compartment: nucleus (probable)
General
phosphoprotein
rad23 homolog
Properties
SIZE: entity length = 363 aa
MW = 40 kD
COMPARTMENT: cell nucleus
MOTIF: Ubiquitin-like {1-81}
Ser phosphorylation site {S123}
Ser phosphorylation site {S128}
Ser phosphorylation site {S133}
UBA 1 {161-201}
Ser phosphorylation site {S205}
Ser phosphorylation site {S295}
UBA 2 {318-358}
HIV-1 Vpr binding {319-363}
MOTIF: Ser phosphorylation site {S357}
Database Correlations
OMIM 600061
UniProt P54725
PFAM correlations
Entrez Gene 5886
Kegg hsa:5886
References
- UniProt :accession P54725
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad23a/
- de Laat WL et al,
Molecular mechonisms of nucleotide excision repair.
Genes & Dev 13:768-85, 1999
PMID: 10197977
- Entrez Gene :accession 5886