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rac S/T kinase; AKT kinase
Function:
- one of 3 serine/threonine protein kinases (AKT1, AKT2 & AKT3)
- regulate many processes including:
a) metabolism
b) proliferation,
c) cell survival
d) growth
e) angiogenesis
- > 100 candidate substrates have been reported so far, but for most of them, no isoform specificity has been reported
- the 3 AKT kinases were long surmised to play redundant & overlapping roles; however, redundancy within AKT kinase isoforms may be limited;
- AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes
- AKT2 is more specific for the insulin receptor signaling
- while AKT1 & AKT2 are often implicated in many aspects of cellular transformation; the 2 isoforms act in a complementary opposing manner
- the role of AKT3 is less clear, though it appears to be predominantly expressed in brain
Structure:
- strong homologies in the primary amino acid sequence of the 3 AKT kinases
Interactions
molecular events
Specific
rac-alpha serine/threonine kinase (AKT1 kinase, protein kinase B)
rac-beta serine/threonine kinase (AKT2 kinase, protein kinase B-beta, PKB beta, AKT2)
RAC-gamma serine/threonine protein kinase; protein kinase Akt-3; protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2 (AKT3, PKBG)
General
serine/threonine kinase
Properties
STATE: active state
MOTIF: S/T phosphorylation site
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
References
- UniProt :accession P31749
- UniProt :accession P31751
- UniProt :accession Q9Y243