Search
rac proto-oncogene protein (p21rac)
The bulk of p21rac is normally complexed to rho-GDI. p21rac has relatively high intrinsic GTPase activity & nucleotide exchange is relatively slow.
Interactions
molecular events
Specific
rac1 proto-oncogene protein; Ras-related C3 botulinum toxin substrate 1; p21-Rac1; Ras-like protein TC25; cell migration-inducing gene 5 protein (RAC1)
rac2 proto-oncogene protein; EN7 protein; Ras-related C3 botulinum toxin substrate 2; p21-Rac2; small G protein; GX (RAC2)
General
rho subfamily protein
Properties
SIZE: MW = 21 kD
COMPARTMENT: cellular compartment
CELL: unspecified cell type
ORGANISM: mammal
MOTIF: active site
P-loop
FOR-BINDING-OF: guanosine triphosphate
guanosine diphosphate
allosteric site
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: GERANYLGERANYL{C-20}
BOUND-VIA: cysteine residue
References
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203
- Segal AW, Abo A.
The biochemical basis of the NADPH oxidase of phagocytes.
Trends Biochem Sci. 1993 Feb;18(2):43-7. Review.
PMID: 8488557
- Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L.
A brain serine/threonine protein kinase activated by Cdc42
and Rac1.
Nature. 1994 Jan 6;367(6458):40-6.
PMID: 8107774
Component-of
molecular complex