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RAB GTPase-activating protein 1-like (RABGAP1L, HHL, KIAA0471)
Structure:
- contains 1 PID domain
- contains 1 Rab-GAP TBC domain
Alternative splicing: named isoforms=9
Pathology:
- up-regulated in esophageal squamous cell carcinomas
- expression is strongly inhibited in the medial septum & hippocampus brain regions of some Alzheimer disease patients
Specific
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L-10, HHL, KIAA0471)
General
rab GTPase-activating protein (rab-GAP)
Properties
SIZE: entity length = 815 aa
MW = 93 kD
MOTIF: Ser phosphorylation site {S118}
phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 126-282
rab-GAP domain
NAME: rab-GAP domain
SITE: 538-724
Database Correlations
OMIM 609238
SWISS-PROT correlations
Pfam PF00566
References
UniProt :accession Q5R372