Search
rab subfamily protein
Function:
- implicated in endocytotic & exocytotic functions
- role in regulation of membrane trafficking, transport of vesicles between different intracellular compartments
Structure:
- Rab proteins may be modified with an internal prenyl group as well as the C-terminal CaaX motif [3]
Comparative biology:
- related to yeast Sec4 & Ypt1 proteins
Interactions
molecular events
Related
rab proto-oncogene
Specific
Rab & DnaJ domain-containing protein (DNAJC27, RBJ, RABJS)
Rab-like protein 2B (RABL2B)
Rab-like protein 3 (RABL3)
Rab-like protein 5 (RABL5)
rab3 proto-oncogene protein
rab4a proto-oncogene protein; Ras-related protein Rab-4A (RAB4A, RAB4)
rab4b proto-oncogene protein; Ras-related protein Rab-4B (RAB4B)
rab5 proto-oncogene protein
rab6 proto-oncogene protein
rab7 proto-oncogene protein; Ras-related protein Rab-7a (RAB7A, RAB7, BRL-ras)
rab7L1 proto-oncogene protein; Ras-related protein Rab-7L1; Rab-7-like protein 1 (RAB7L1)
rab8a proto-oncogene protein; Ras-related protein Rab-8A; mel proto-oncogene protein (RAB8A, MEL, RAB8)
rab8b proto-oncogene protein; Ras-related protein Rab-8B (RAB8B)
rab9a proto-oncogene protein; Ras-related protein Rab-9A; Rab-9A (RAB9A, RAB9)
rab9b proto-oncogene protein; Ras-related protein Rab-9B; Rab-9L; RAB9-like protein (RAB9B, RAB9L)
rab10 proto-oncogene protein
rab11a proto-oncogene protein; Ras-related protein Rab-11A; Rab-11; 24KG; YL8 (RAB11A. RAB11)
rab11b proto-oncogene protein; Ras-related protein Rab-11B; GTP-binding protein YPT3 (RAB11B, YPT3)
rab12 proto-oncogene protein; Ras-related protein Rab-12 (RAB12)
rab13 proto-oncogene protein; Ras-related protein Rab-13; cell growth-inhibiting gene 4 protein (RAB13)
rab14 proto-oncogene protein
rab15 proto-oncogene protein; Ras-related protein Rab-15 (RAB15)
rab17 proto-oncogene protein; Ras-related protein Rab-17 (RAB17)
rab18 proto-oncogene protein; Ras-related protein Rab-18 (RAB18)
rab19 proto-oncogene protein (Ras-related protein Rab-19, RAB19, RAB19B)
rab20 proto-oncogene protein; Ras-related protein Rab-20 (RAB20)
rab21 proto-oncogene protein; Ras-related protein Rab-21 (RAB21, KIAA0118)
rab22a proto-oncogene protein
rab23 proto-oncogene protein; Ras-related protein Rab-23 (RAB23)
rab24 proto-oncogene protein; Ras-related protein Rab-24 (RAB24)
rab25 proto-oncogene protein (CATX-8)
rab26 proto-oncogene protein; Ras-related protein Rab-26 (RAB26)
rab27a proto-oncogene protein; Ras-related protein Rab-27A; Rab-27; GTP-binding protein Ram (RAB27A, RAB27)
rab27b proto-oncogene protein; Ras-related protein Rab-27B; C25KG (RAB27B)
rab28 proto-oncogene protein; Ras-related protein Rab-28; Rab-26 (RAB28)
rab29 proto-oncogene protein
rab30 proto-oncogene protein; Ras-related protein Rab-30 (RAB30)
rab32 proto-oncogene protein; Ras-related protein Rab-32 (RAB32)
rab33a proto-oncogene protein; Ras-related protein Rab-33A; small GTP-binding protein S10 (RAB33A, RABS10)
rab33b proto-oncogene protein; Ras-related protein Rab-33B (RAB33B)
rab34 proto-oncogene protein; Ras-related protein Rab-34; Rab-39; Ras-related protein Rah (RAB34, RAB39, RAH)
rab35 proto-oncogene protein; Ras-related protein Rab-35; Rab-1C; GTP-binding protein RAY (RAB35, RAB1C, RAY)
rab36 proto-oncogene protein; Ras-related protein Rab-36 (RAB36)
rab38 proto-oncogene protein; Ras-related protein Rab-38; antigen NY-MEL-1 (RAB38)
rab39a proto-oncogene protein; Ras-related protein Rab-39A; Rab-39 (RAB39, RAB39A)
rab39b proto-oncogene protein; Ras-related protein Rab-39B (RAB39B)
rab40 proto-oncogene protein
rab41 proto-oncogene protein; Ras-related protein Rab-41 (RAB41)
rab42 proto-oncogene protein; Ras-related protein Rab-42 (RAB42)
ram proto-oncogene protein
Ras-related protein Rab-1A; YPT1-related protein (RAB1A RAB1)
Ras-related protein Rab-1B (RAB1B)
Ras-related protein Rab-1C (hRab1c, RAB1C)
Ras-related protein Rab-2A (RAB2A RAB2)
Ras-related protein Rab-2B (RAB2B)
Ras-related protein Rab-37 (RAB37)
Ras-related protein Rab-40A-like (RAB40AL)
Ras-related protein Rab-43 (RAB43)
Ras-related protein Rab-7b (RAB7B)
small GTP-binding protein 25B (smg 25B)
small GTP-binding protein 25C (smg 25C)
General
prenyl protein
proto oncogene protein
ras superfamily protein
Properties
SIZE: MW = 20-29 kD
COMPARTMENT: cellular membrane
MOTIF: active site
P-loop
FOR-BINDING-OF: guanosine triphosphate
guanosine diphosphate
cysteine residue {C-TERMINAL}
MODIFICATION: prenyl
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: prenyl
BOUND-VIA: cysteine residue
References
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203
- Boguski MS & McCormick F
Proteins regulating Ras and its relatives.
Nature 366:643 1993
PMID: 8259209
- Casey PJ
Protein lipidation in cell signaling.
Science 268:221 1995
PMID: 7716512
Component-of
molecular complex