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rab6a proto-oncogene protein; Ras-related protein Rab-6A; Rab-6 (RAB6A, RAB6)

Function: 1) retrograde GOLGI-ER & intra-GOLGI traffic 2) motility of GOLGI-ER vesiclesFunction: protein transport 3) has a low GTPase activity 4) phosphorylated upon DNA damage, probably by ATM or ATR 5) interacts with SCYL1BP1 6) interacts with VSP52 & RABGAP1. 7) isoform 1 interacts with RAB6KIFL; isoform 2 does not 8) isoforms 1 & 2 interact with BICD1 & BICD2 Structure: - belongs to the small GTPase superfamily, Rab family Compartment: Golgi apparatus membrane; lipid-anchor Alternative splicing: named isoforms=2 Expression: ubiquitous

Related

kinesin-like protein KIF20A (rabkinesin-6, rab6-interacting kinesin- like protein, GG10-2, KIF20A, RAB6KIFL) rab-6a proto-oncogene rab6 GTPase-activating protein (rab6-GAP) or GYP6

General

rab6 proto-oncogene protein

Properties

SIZE: MW = 24 kD entity length = 208 aa COMPARTMENT: ENDOPLASMIC-RECTICULUM golgi golgi MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl GTP-binding site SITE: 20-27 Effector region {42-50} GTP-binding site SITE: 68-72 GTP-binding site SITE: 126-129 Thr phosphorylation site {T180} cysteine residue {C206} MODIFICATION: geranylgeranyl{C20} cysteine residue {C208} MODIFICATION: geranylgeranyl{C20}

Database Correlations

OMIM 179513 UniProt P20340 Pfam PF00071 Entrez Gene 5870 Kegg hsa:5870

References

  1. UniProt :accession P20340
  2. Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M. Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. Nature. 1991 Apr 25;350(6320):715-8. PMID: 1902553
  3. Seabra MC et al Rab GTPases, intracellular traffic and disease Trends in Molecular Medicine 8:23, 2002 PMID: 11796263
  4. Entrez Gene :accession 5870