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rab5a proto-oncogene protein; Ras-related protein Rab-5A (RAB5A, RAB5)
Function:
1) plasma membrane-early endosome transport
2) early endosome fusion & mobility
3) regulated by guanine nucleotide exchange factors (GEFs) which promote exchange of bound GDP for free GTP
4) binds EEA1
5) interacts with RIN1 & GAPVD1, which regulate its pathway, probably by acting as a GEF
6) interacts with ALS2CL, UNC84B, ZFYVE20 & RUFY1
7) interacts with SGSM1 & SGSM3
Structure: belongs to the small GTPase superfamily, Rab family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative)
- early endosome membrane; lipid-anchor
- melanosome; enriched in stage I melanosomes
Related
rab-5a proto-oncogene
General
phosphoprotein
rab5 proto-oncogene protein
Properties
SIZE: entity length = 215 aa
MW = 24 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 27-34
Effector region {49-57}
GTP-binding site
SITE: 75-79
GTP-binding site
SITE: 133-136
Thr phosphorylation site {T202}
Thr phosphorylation site {T205}
Thr phosphorylation site {T208}
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 179512
UniProt P20339
Pfam PF00071
Entrez Gene 5868
Kegg hsa:5868
References
- Seabra MC et al
Rab GTPases, intracellular traffic and disease
Trends in Molecular Medicine 8:23, 2002
PMID: 11796263
- Entrez Gene :accession 5868
- UniProt :accession P20339