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rab4a proto-oncogene protein; Ras-related protein Rab-4A (RAB4A, RAB4)
Function:
- protein transport.
- probably involved in vesicular traffic (putative)
- early endosome-plasma membrane sorting & recycling
- phosphorylated by CDC2 kinase during mitosis
- interacts with RAB11FIP1, RABEP1, ZFYVE20 & RUFY1
- interacts with SGSM1, SGSM2 & SGSM3 (putative)
Structure: belongs to the small GTPase superfamily, Rab family
Compartment:
- membrane; peripheral membrane protein
- cytoplasm
- generally associated with membranes
- cytoplasmic when phosphorylated by CDC2
Interactions
molecular events
Related
rab-4a proto-oncogene
General
phosphoprotein
rab subfamily protein
Properties
SIZE: entity length = 213 aa
MW = 24 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 15-22
Effector region {37-45}
GTP-binding site
SITE: 63-67
GTP-binding site
SITE: 121-124
Ser phosphorylation site {S199}
cysteine residue {C211}
MODIFICATION: geranylgeranyl{C20}
cysteine residue {C213}
MODIFICATION: geranylgeranyl{C20}
Database Correlations
OMIM 179511
UniProt P20338
Pfam PF00071
Entrez Gene 5867
Kegg hsa:5867
References
- Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B,
Bornens M.
Phosphorylation of two small GTP-binding proteins of the Rab
family by p34cdc2.
Nature. 1991 Apr 25;350(6320):715-8.
PMID: 1902553
- Seabra MC et al
Rab GTPases, intracellular traffic and disease
Trends in Molecular Medicine 8:23, 2002
PMID: 11796263
- Entrez Gene :accession 5867
- UniProt :accession P20338