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rab20 proto-oncogene protein; Ras-related protein Rab-20 (RAB20)
Function: plays a role in apical endocytosis/recycling
Structure: belongs to the small GTPase superfamily, Rab family
Compartment:
- Golgi
- highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (putative)
Expression:
- low or absent expression in normal pancreas
Pathology:
- stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level)
Related
rab-20 proto-oncogene
General
rab subfamily protein
Properties
SIZE: entity length = 234 aa
MW = 26 kD
COMPARTMENT: golgi
endosome
MOTIF: GTP-binding site
SITE: 12-19
Effector region {33-41}
GTP-binding site
SITE: 55-59
GTP-binding site
SITE: 113-116
cysteine residue {C232}
MODIFICATION: geranylgeranyl{C20}
cysteine residue {C233}
MODIFICATION: geranylgeranyl{C20}
Database Correlations
UniProt Q9NX57
Pfam PF00071
Entrez Gene 55647
Kegg hsa:55647
References
- Seabra MC et al
Rab GTPases, intracellular traffic and disease
Trends in Molecular Medicine 8:23, 2002
PMID: 11796263
- Entrez Gene :accession 55647
- UniProt :accession Q9NX57