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rab13 proto-oncogene protein; Ras-related protein Rab-13; cell growth-inhibiting gene 4 protein (RAB13)
Function:
- formation of epithelial tight junctions
- could participate in polarized transport, in the assembly &/or the activity of tight junctions
Structure: belongs to the small GTPase superfamily, Rab family
Compartment:
- cell junction, tight junction
- cell membrane; lipid-anchor; cytoplasmic side
- cytoplasmic vesicle membrane; lipid-anchor; cytoplasmic side
- cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions
Expression:
- detected in several types of epithelia, including intestine, kidney, liver & in endothelial cells
Related
rab-13 proto-oncogene
General
phosphoprotein
rab subfamily protein
Properties
SIZE: entity length = 203 aa
MW = 23 kD
COMPARTMENT: cytoplasm
tight junction
MOTIF: GTP-binding site
SITE: 15-22
Effector region {37-45}
GTP-binding site
SITE: 63-67
GTP-binding site
SITE: 121-124
Ser phosphorylation site {S178}
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 602672
UniProt P51153
Pfam PF00071
Entrez Gene 5872
Kegg hsa:5872
References
- Seabra MC et al
Rab GTPases, intracellular traffic and disease
Trends in Molecular Medicine 8:23, 2002
PMID: 11796263
- Entrez Gene :accession 5872
- UniProt :accession P51153