Rab11 family-interacting protein 5 (Rab11-FIP5, Rab11-interacting protein Rip11, gamma-SNAP-associated factor 1, Gaf-1, phosphoprotein pp75, RAB11FIP5, GAF1, KIAA0857, RIP11)

Function: 1) Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane 2) forms heterooligomeric complex with RAB11FIP4 3) binds NAPG & SSA2 4) binds RAB11A activated by GTP binding 5) binds to vesicles enriched in neutral phospholipids via its C2 domain 6) interaction is favored by Mg⁺² rather than Ca⁺² 7) phosphorylated on Ser & Thr Structure: - contains 1 C2 domain Compartment: - cytoplasm, recycling endosomal membrane, peripheral membrane mitochondrial membrane Expression: - expressed at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle, pancreas Pathology: - antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjogren syndrome & in the sera from mothers of children with neonatal lupus erythematosus

Properties

SIZE: MW = 70 kD entity length = 653 aa COMPARTMENT: mitochondria cytoplasm endosome MOTIF: C2 domain {6-128} MOTIF: binding site FOR-BINDING-OF: phospholipid Ca+2-binding site Ser phosphorylation site {S174} Ser phosphorylation site {S307}

Database Correlations

OMIM 605536 UniProt Q9BXF6 Pfam PF00168

References

UniProt :accession Q9BXF6