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rab11a proto-oncogene protein; Ras-related protein Rab-11A; Rab-11; 24KG; YL8 (RAB11A. RAB11)
Function:
- endocytic recycling via endosomes & trans GOLGI network; modulates endosomal trafficking (putative)
- interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 & RAB11FIP4
- binds RIP11 & STXBP6.
- interacts with SGSM1, SGSM2 & SGSM3 (putative)
Structure: belongs to the small GTPase superfamily, Rab family
Compartment:
- cell membrane; peripheral membrane protein
- recycling endosome membrane
- translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane
Related
rab-11a proto-oncogene
General
rab subfamily protein
Properties
SIZE: entity length = 216 aa
MW = 24 kD
COMPARTMENT: endosome
golgi
plasma membrane
MOTIF: GTP-binding site
SITE: 18-25
Effector region {40-48}
GTP-binding site
SITE: 66-70
GTP-binding site
SITE: 124-127
cysteine residue {C212}
MODIFICATION: geranylgeranyl{C20}
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: geranylgeranyl{C20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 605570
UniProt P62491
Pfam PF00071
Entrez Gene 8766
Kegg hsa:8766
References
- Seabra MC et al
Rab GTPases, intracellular traffic and disease
Trends in Molecular Medicine 8:23, 2002
PMID: 11796263
- Entrez Gene :accession 8766
- UniProt :accession P62491