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zeta-crystallin; quinone oxidoreductase; NADPH:quinone reductase (CRYZ)
Function:
- does not have alcohol dehydrogenase activity
- binds NADP & acts through a one-electron transfer process
- orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro)
- may act in the detoxification of xenobiotics
- interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species
- enhances the stability of mRNA coding for BCL2
- NADPH binding interferes with mRNA binding
NADPH + 2 quinone = NADP+ + 2 semiquinone
Structure:
- homotetramer
- belongs to the Zn+2-containing alcohol dehydrogenase family, quinone oxidoreductase subfamily
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression: only very low amounts found in the lens
General
crystallin
quinone reductase
Properties
SIZE: entity length = 329 aa
MW = 35 kD
COMPARTMENT: cytoplasm
MOTIF: cofactor-binding site [53-53]
COFACTOR-BOUND: NADP
cofactor-binding site [158-161]
COFACTOR-BOUND: NADP
cofactor-binding site [181-181]
COFACTOR-BOUND: NADP
cofactor-binding site [200-200]
COFACTOR-BOUND: NADP
cofactor-binding site [229-229]
COFACTOR-BOUND: NADP
cofactor-binding site [246-249]
COFACTOR-BOUND: NADP
cofactor-binding site [269-271]
COFACTOR-BOUND: NADP
Database Correlations
OMIM 123691
UniProt Q08257
PFAM correlations
Entrez Gene 1429
Kegg hsa:1429
ENZYME 1.6.5.5
References
- UniProt :accession Q08257
- Entrez Gene :accession 1429