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pyruvate kinase in erythrocytes

Indications: - evaluation of pyruvate kinase deficiency - evaluation of pyruvate kinase hyperactivity Notes: - leukocytes must be removed from the sample, because - leukocytes normally contain 300 fold as much pyruvate kinase as do erythrocytes - it is the erythrocytes that are deficient in pyruvate kinase not the leukocytes

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pyruvate kinase

General

pyruvate kinase measurement

References

  1. Henry's Clinical Diagnosis & Management by Laboratory Methods, 21st edition, McPherson RA & Pincus MR (es), W.B. Saunders Co., Philadelphia, PA. 2007
  2. PubMed Health: Pyruvate kinase deficiency http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002177/
  3. Pyruvate Kinase Laboratory Test Directory ARUP: 80290

Component-of

pyruvate kinase/pyruvate kinase/glucose-6-phosphate dehydrogenase in erythrocytes