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pyruvate kinase
Expression:
- there are 4 isozymes of pyruvate kinase in mammals: L, R, M1 & M2
- L type is major isozyme in the liver
- R is found in red cells
- M1 is the main form in muscle, heart & brain
- M2 is found in early fetal tissues
Genetics:
- L & R isoforms from same gene, by alternative splicing
- M1 & M2 isoforms from same gene, by alternative splicing
Interactions
molecular events
Related
glycolytic pathway (glycolysis, Embden Myerhof pathway)
pyruvate kinase genotyping
pyruvate kinase in erythrocytes
pyruvate kinase measurement
Specific
pyruvate kinase A-type
pyruvate kinase L-type (pyruvate kinase R/L, PKLR)
pyruvate kinase M-type (PKM)
General
glycolytic enzyme
kinase or ATP-phosphotransferase
oligomerizing protein
Properties
CONFIGURATION: tetramer
SIZE: MW = 55 kD
COMPARTMENT: cytoplasm
MOTIF: active site
Database Correlations
OMIM 179050
ENZYME 2.7.1.40
References
Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 362