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phenazopyridine (Pyridium, Azo-Standard, Uristat, Prodium)
Tradename: Pyridium.
Indications:
- symptomatic relief of dysuria*
- pain, burning, urinary urgency & urinary frequency arising from irritation of the lower urinary tract
- caused by urinary tract infection
- following urological procedures
* does NOT provide antimicrobial coverage
Dosage:
1) 100-200 mg PO TID after meals for 2 days
2) do NOT use chronically
3) adequate hydration is needed
Tabs: 100 & 200 mg.
Adverse effects:
1) not common (1-10%)
- headache, dizziness, epigastric cramps
2) uncommon (< 1%)
- vertigo, skin pigmentation, rash, methemoglobinemia, hemolytic anemia, hepatitis, acute renal failure
3) other
a) anaphylactoid-like reactions
b) will turn urine orange [5]
c) will stain clothes & contact lenses
Mechanism of action:
- azo dye that exerts a topical analgesic effect on the urinary mucosal tract
General
analgesic (antalgic)
pyridine
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
- Atalla AS, Palka J
12 Causes of Discolored Urine.
Medscape. Nov 15, 2017
https://reference.medscape.com/slideshow/discolored-urine-6008332
Component-of
butabarbital/hyoscyamine/phenazopyridine
oxytetracycline/phenazopyridine
phenazopyridine/sulfamethoxazole/trimethoprim