pyrin & HIN domain-containing protein 1 (interferon-inducible protein X, PYHIN1, IFIX)

Function: - major mediator of the tumor suppressor activity of IFN in breast cancer cells - promotes ubiquitination & subsequent degradation of MDM2, which leads to p53/TP53 stabilization - promotes ubiquitination & subsequent degradation of HDAC1, which in turn enhances maspin expression, & impairs invasive activity of cancer cells - interacts with MDM2 Structure: - HIN-200 domain mediates interaction with MDM2 belongs to the HIN-200 family - contains 1 DAPIN domain - contains 1 HIN-200 domain Compartment: - isoform 1: nucleus, nucleoplasm - isoform 3: nucleus, nucleoplasm - isoform 5: nucleus, in speckles Alternative splicing: named isoforms=6 Expression: - expressed in spleen, lymph node & peripheral blood leukocytes, & at lower levels in thymus, bone marrow & fetal liver - induced by IFNalpha & IFNgamma in hematopoietic cancer cells Pathology: - down-regulated in breast tumors

Properties

GENERAL: uncharacterized protein SIZE: entity length = 492 aa MW = 55 kD COMPARTMENT: cell nucleus FORM: pyrin & HIN domain-containing protein 1 MOTIF: DAPIN domain {1-88} HIN-200 domain {199-399}

Database Correlations

UniProt Q6K0P9 PFAM correlations Kegg hsa:1496

References

UniProt :accession Q6K0P9