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pygopus homolog 1 (PYGO1)
Function:
- role in signal transduction through the Wnt pathway
- binds to BCL9 via the PHD-type Zn+2 finger motif, & becomes part of the nuclear beta-catenin/TCF complex
- found in a complex with BCL9L, CDC73, CTNNB1 & PYGO1
Structure: contains 1 PHD-type Zn+2 finger
Compartment: nucleus (probable)
General
pygopus homolog
zinc finger protein
Properties
SIZE: entity length = 419 aa
MW = 45 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {35-41}
proline-rich region
SITE: 47-135
MOTIF: proline residue (SEVERAL)
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 340-398
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 606902
UniProt Q9Y3Y4
Pfam PF00628
Entrez Gene 26108
Kegg hsa:26108
References
UniProt :accession Q9Y3Y4