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Poliovirus receptor-related protein 4 (Nectin-4, Ig superfamily receptor LNIR, [Contains: processed poliovirus receptor-related protein 4], PVRL4, LNIR, PRR4)
Function:
- seems to be involved in cell adhesion through trans-homophilic & -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1
- does not act as receptor for alpha-herpesvirus entry into cells
- self-associates
- interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain
- interacts via its C-terminus with MLLT4
- soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE
Structure:
- belongs to the nectin family
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment:
- membrane (putative), cell junction, adherens junction
- colocalizes with MLLT4 at cadherin-based adherens junctions
- processed poliovirus receptor-related protein 4: secreted
Expression:
- predominantly expressed in placenta
- not detected in normal breast epithelium
Pathology:
- expressed in breast carcinoma
- secreted form is found in breast cancer patients
Related
polio virus
poliovirus receptor; nectin-like protein 5; necl-5; CD155 (PVR, PVS)
General
immunoglobulin superfamily protein
membrane protein
Properties
SIZE: entity length = 510 aa
MW = 55 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-31}
immunoglobulin superfamily domain {32-144}
immunoglobulin superfamily domain {148-237}
MOTIF: cysteine residue {C171}
MODIFICATION: cysteine residue {C223}
cysteine residue {C223}
MODIFICATION: cysteine residue {C171}
immunoglobulin superfamily domain {248-331}
MOTIF: cysteine residue {C270}
MODIFICATION: cysteine residue {C315}
N-glycosylation site {N281}
cysteine residue {C315}
MODIFICATION: cysteine residue {C270}
transmembrane domain {350-370}
Database Correlations
UniProt Q96NY8
PFAM correlations
References
UniProt :accession Q96NY8