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purine nucleoside phosphorylase; inosine phosphorylase (NP, PNP)
Function:
purine nucleoside + phosphate
purine + alpha-D-ribose 1-phosphate
Structure:
- homotrimer
- belongs to the PNP/MTAP phosphorylase family
Pathology:
- defects in NP are the cause of nucleoside phosphorylase deficiency
General
glycosyltransferase
phosphotransferase
Properties
SIZE: entity length = 289 aa
MW = 32 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
active site
Database Correlations
OMIM 164050
UniProt P00491
Pfam PF01048
Entrez Gene 4860
Kegg hsa:4860
ENZYME 2.4.2.1
References
- UniProt :accession P00491
- NPbase; Note: NP mutation db
http://bioinf.uta.fi/NPbase/
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=NP