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pure autonomic failure (PAF)
slowly progressive degeneration of the autonomic nervous system.
Epidemiology: sporadic, adult onset
Pathology:
- Lewy bodies/inclusions
- brainstem
- pre- and post-ganglionic autonomic neurons
- peripheral sympathetic nerves & parasympathetic nerves
Clinical manifestations:
- isolated autonomic impairment
- orthostatic hypotension
Interactions
disease interactions
General
synucleinopathy (includes alpha-synucleinopathy)
References
- Kaufmann H, Biaggioni I.
Autonomic Failure in Neurodegenerative Disorders
Seminars in Neurology 23(4):351-363, 2003
PMID: 15088256