PTW/PP1 phosphatase complex

Function: - role in control of chromatin structure & cell cycle progression during the transition from mitosis into interphase Structure: - subunits include: PPP1R10/PNUTS, TOX4, WDR82, & PPP1CA or PPP1CB or PPP1CC

Properties

SUBUNITS: protein phosphatase-1 regulatory subunit 10 COMPARTMENT: cell nucleus MOTIF: TFS2-N {74-146} lysine-rich region {304-310} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S398} FOR-PHOSPHORYLATION-BY: protein kinase A Thr phosphorylation site {T400} FOR-PHOSPHORYLATION-BY: protein kinase A allosteric site proline-rich region glycine-rich region {540-904} Zinc finger NAME: Zinc finger SITE: 907-933 EFFECTOR-BOUND: Zn+2 INHIBITS: phosphatase TOX high mobility group box family member 4 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S182} HMG box SITE: 223-291 proline-rich region SITE: 401-534 MOTIF: proline residue (SEVERAL) alanine-rich region {426-434} MOTIF: alanine residue (SEVERAL) WD repeat protein 82 MOTIF: WD repeat {19-58} WD repeat {105-144} WD repeat {146-184} WD repeat {192-231} WD repeat {236-276} WD repeat {280-313} serine/threonine protein phosphatase PP1-alpha catalytic subunit COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Iron [Fe]-binding site SITE: 64-64 Iron [Fe]-binding site SITE: 66-66 Iron [Fe]-binding site SITE: 92-92 MOTIF: manganese [Mn]-binding site SITE: 92-92 manganese [Mn]-binding site SITE: 124-124 histidine residue {H125} manganese [Mn]-binding site SITE: 173-173 manganese [Mn]-binding site SITE: 248-248 Tyr phosphorylation site {Y306} Thr phosphorylation site {T320} STATE: active state

References

UniProt :accession P62136

Components

protein phosphatase-1 regulatory subunit 10 (phosphatase 1 nuclear targeting subunit, MHC class I region proline rich protein CAT53, FB19 protein, PP1-binding protein of 114 kD, p99, PPP1R10, CAT53, FB19, PNUTS) serine/threonine protein phosphatase PP1-alpha catalytic subunit; PP-1A (PPP1CA, PPP1A) TOX high mobility group box family member 4 (epidermal Langerhans cell protein LCP1, TOX4, C14orf92, KIAA0737) WD repeat protein 82 (WDR82)