receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2 (PTPRN, ICA3, ICA512)

Function: - implicated in neuroendocrine secretory processes - may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions - seems to lack intrinsic enzyme activity - may play a role in the regulation of secretory granules via its interaction with SNTB2 - appears to undergo multiple proteolytic cleavage at consecutive basic residues - interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1 - dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction & results in its cleavage Structure: - belongs to the protein-tyrosine phosphatase family receptor class 8 subfamily - contains 1 tyrosine-protein phosphatase domain Compartment: - membrane; single-pass type 1 membrane protein - neuroendocrine secretory granules Expression: - expression is restricted to neuroendocrine cells - found in pancreas, brain & pituitary Pathology: - autoantigen in insulin-dependent diabetes mellitus (IDDM) Laboratory: - islet antigen 2 antibody in serum

General

receptor tyrosine phosphatase, receptor type

Properties

SIZE: entity length = 979 aa MW = 106 kD COMPARTMENT: cellular membrane STATE: active state MOTIF: signal sequence {1-34} proteolytic site {448-449} N-glycosylation site {N506} N-glycosylation site {N524} transmembrane domain {576-600} Tyrosine-protein phosphatase {709-969} MOTIF: Substrate binding {909-915} cysteine residue {C909}

Database Correlations

OMIM 601773 UniProt Q16849 PFAM correlations Entrez Gene 5798 KEGG correlations

References

UniProt :accession Q16849