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protein tyrosine phosphatase 12, non-receptor type; protein-tyrosine phosphatase G1 (PTPN12, PTP-G1, PTPG1, PTP-PEST)
Function:
- interacts with TGFB1I1 (putative)
- interacts with PSTPIP1
Structure:
- belongs to the protein-tyrosine phosphatase family non-receptor class 4 subfamily
- contains 1 tyrosine-protein phosphatase domain
Compartment: cytoplasm
Pathology:
- defects in PTPN12 are found in some colon cancers
General
tyrosine phosphatase, non-receptor type
Properties
SIZE: entity length = 780 aa
MW = 88 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyrosine-protein phosphatase {28-293}
MOTIF: Ser phosphorylation site {S186}
cysteine residue {C231}
Ser phosphorylation site {S332}
TGFB1I1 interaction {345-438}
Thr phosphorylation site {T569}
Ser phosphorylation site {S571}
Ser phosphorylation site {S596}
Thr phosphorylation site {T598}
Ser phosphorylation site {S603}
Ser phosphorylation site {S606}
Ser phosphorylation site {S608}
Ser phosphorylation site {S673}
Ser phosphorylation site {S689}
Thr phosphorylation site {T693}
Database Correlations
OMIM 600079
MORBIDMAP 600079
UniProt Q05209
Pfam PF00102
Entrez Gene 5782
Kegg hsa:5782
ENZYME 3.1.3.48
References
UniProt :accession Q05209