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protein tyrosine phosphatase non-receptor type 1; protein tyrosine phosphatase 1B (PTPN1, PTP1B)
Function:
- may play an important role in CKII- & p60c-src-induced signal transduction cascades (putative)
- oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding & activity
- active site can be restored by reduction
Structure:
- belongs to the protein-tyrosine phosphatase family non-receptor class 1 subfamily
- contains 1 tyrosine-protein phosphatase domain
Compartment:
- endoplasmic reticulum membrane, cytoplasmic side
Polymorphism:
- genetic variation in PTPN1 may influence abdominal body fat distribution
General
placental protein
tyrosine phosphatase, non-receptor type
Properties
SIZE: entity length = 435 aa
MW = 50 kD
COMPARTMENT: cytoplasm
endoplasmic reticulum
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyrosine-protein phosphatase {3-277}
MOTIF: Tyr phosphorylation site {Y20}
Ser phosphorylation site {S50}
cysteine residue {C215}
Ser phosphorylation site {S295}
Ser phosphorylation site {S352}
Ser phosphorylation site {S378}
Ser phosphorylation site {S386}
Ser phosphorylation site {S393}
STATE: active state
Database Correlations
OMIM 176885
UniProt P18031
Pfam PF00102
Entrez Gene 5770
KEGG correlations
ENZYME 3.1.3.48
References
- Rohan PJ, Davis P, Moskaluk CA, Kearns M, Krutzsch H,
Siebenlist U, Kelly K.
PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase.
Science. 1993 Mar 19;259(5102):1763-6.
PMID: 7681221
- Barford D, Flint AJ, Tonks NK.
Crystal structure of human protein tyrosine phosphatase 1B.
Science. 1994 Mar 11;263(5152):1397-404.
PMID: 8128219
- UniProt :accession P18031