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prostaglandin E synthase 2 (microsomal prostaglandin E synthase 2, mPGES-2, PTGES2, PGES2)
Function:
1) isomerase intermediate of prostaglandin E2 H2 (PGH2) into more stable prostaglandin E2 (PGE2) form
2) transactivation activity toward IFN-gamma via interaction with CEBPB (putative, relevance uncertain)
3) cofactor: dihydro lipoic acid
4) prostaglandin biosynthesis 5)interact with CEBPB (putative), EXOSC1
Structure: homodimer
Compartment:
- Golgi membrane
- processed form: cytoplasm, perinuclear region
Expression:
- widely expressed in adult & heart but not aorta
- expressed in brain: cerebellum; occipital lobe, frontal lobe & parietal lobes
- expressed in the lymph nodes, skeletal muscle, kidney, trachea
- not expressed in thymus, lung
Pathology:
- overexpressed in colorectal cancer
General
isomerase
membrane protein
Properties
SIZE: MW = 42 kD
entity length = 377 aa
COMPARTMENT: cytoplasm
cell nucleus
golgi
MOTIF: transmembrane domain {58-74}
proteolytic site {87-88}
cysteine residue {C110}
Database Correlations
OMIM 608152
UniProt Q9H7Z7
PFAM correlations
ENZYME 5.3.99.3
References
UniProt :accession Q9H7Z7