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prostaglandin D2 receptor DP1 (Prostanoid DP receptor, PGD receptor)
Function:
- receptor for prostaglandin D2 (PGD2)
- activity mediated by Gs proteins that stimulate adenylate cyclase & increase intracellular cAMP
- mobilization of Ca+2 also occurs, but without formation of IP3
- neuroprotective for hippocampal pyramidal neurons in paradigms of glutamate toxicity [2]; this contrasts with activation of CRTH2 (DP2) which promotes neuronal loss [2]
- BW245C is agonist
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression: expressed in retina & small intestine
Pathology:
- genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1
Related
G protein-coupled receptor GPR44; prostaglandin D2 receptor DP2; chemoattractant receptor-homologous molecule expressed on Th2 cells (PTGDR2, CRTH2, DP2)
General
glycoprotein
prostaglandin receptor
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 40 kD
entity length = 359 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-21}
MOTIF: N-glycosylation site {N10}
transmembrane domain {22-42}
cytoplasmic loop {43-59}
transmembrane domain {60-80}
exoplasmic loop {81-107}
MOTIF: N-glycosylation site {N90}
cysteine residue {C105}
MODIFICATION: cysteine residue {C183}
transmembrane domain {108-128}
cytoplasmic loop {129-150}
transmembrane domain {151-171}
exoplasmic loop {172-195}
MOTIF: cysteine residue {C183}
MODIFICATION: cysteine residue {C105}
transmembrane domain {196-216}
cytoplasmic loop {217-262}
transmembrane domain {263-283}
exoplasmic loop {284-310}
MOTIF: N-glycosylation site {N297}
transmembrane domain {311-331}
cytoplasmic domain {332-359}
Database Correlations
OMIM 604687
UniProt Q13258
Pfam PF00001
References
- OMIM :accession 604687
- Liang X, Wu L, Hand T, Andreasson K.
Prostaglandin D2 mediates neuronal protection via the DP1 receptor.
J Neurochem. 2005 Feb;92(3):477-86.
PMID: 15659218