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MMAC1 or PTEN gene
Genetics:
- chromosome 10q23.3
Laboratory:
- PTEN gene in cancer
Related
mutated in multiple advanced cancers 1; protein tyrosine phosphatase PTEN; phosphatase & tensin homolog deleted on chromosome ten; phosphatase & tensin homolog; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase & dual-specificity protein phosphatase PTEN (PTEN, MMAC1, TEP1)
General
tumor suppressor gene or anti-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: protein tyrosine phosphatase PTEN
SIZE: entity length = 5.5 KB
LOCUS: human chromosome-10 Q23.3
MOTIF: CpG island
p53-response element
transcriptional start site
exon (9)
intron (8)
transcriptional termination site
Database Correlations
OMIM 601728
MORBIDMAP 601728
References
- Steck PA, Pershouse MA, Jasser SA et al.
Identification of a candidate tumour suppressor gene, MMAC1,
at chromosome 10q23.3 that is mutated in multiple advanced
cancers.
Nature Genetics 15:356-362 1997
PMID: 9090379
- Li J, Yen C, Liaw D, Podsypanina K et al.
PTEN, a putative protein tyrosine phosphatase gene mutated in
human brain, breast, and prostate cancer.
Science. 1997 Mar 28;275(5308):1943-7.
PMID: 9072974 Free Article
- Stambolic V, MacPherson D, Sas D et al.
Regulation of PTEN transcription by p53.
Molecular Cell 8:317-325 2001
PMID: 11545734 Free Article