polypyrimidine tract-binding protein 2 (neurally-enriched homolog of PTB, neural polypyrimidine tract-binding protein, PTB-like protein, PTBP2, NPTB, PTB, PTBLP)

Function: 1) RNA-binding protein 2) binds to intronic polypyrimidine tracts & mediates negative regulation of exon splicing 3) antagonizes ability of NOVA1 to activate exon selection (tissue-specific) 4) role in regulation of translation 5) interacts with NOVA1 & NOVA2 6) part of a ternary complex containing KHSRP & HNRPH1 Structure: - monomer - contains 4 RRM domains (RNA recognition motif) Compartment: nucleus Alternative splicing: named isoforms=6 Expression: - mainly expressed in brain - also detected in other tissues, including heart & skeletal muscle - isoforms 1 & 2 are specifically expressed in neuronal tissues - isoforms 3 & 4 are expressed in non-neuronal tissues - isoforms 5 & 6 are truncated forms expressed in non-neuronal tissues

General

phosphoprotein RNA-binding protein

Properties

SIZE: MW = 57 kD entity length = 531 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S27} RNP motif NAME: RNP motif SITE: 59-133 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 181-257 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S308} alanine-rich region {315-324} MOTIF: alanine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 338-412 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 455-529 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

OMIM 608449 UniProt Q9UKA9 Pfam PF00076

References

UniProt :accession Q9UKA9