26S proteasome regulatory subunit S5A selections

26S proteasome regulatory subunit S5A (26S proteasome non-ATPase regulatory subunit 4, Rpn10, multiubiquitin chain binding protein, antisecretory factor-1, AF, ASF, PSMD4, MCB1)

Function: - binds & presumably selects ubiquitin-conjugates for destruction - displays selectivity for longer polyubiquitin chains - modulates intestinal fluid secretion - directly interacts with NUB1 - interacts with SQSTM1 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way - belongs to the proteasome subunit S5A family - contains 2 UIM (ubiquitin-interacting motif) repeats - contains 1 VWFA domain Alternative splicing: named isoforms=2

General

26S proteasome subunit phosphoprotein

Properties

SIZE: entity length = 377 aa MW = 41 kD MOTIF: VWFA domain {5-188} UIM {211-230} MOTIF: binding site SITE: 216-220 FOR-BINDING-OF: ubiquitin alanine-rich region {238-246} MOTIF: alanine residue (SEVERAL) Thr phosphorylation site {T250} Ser phosphorylation site {S256} Ser phosphorylation site {S266} UIM {282-301} MOTIF: binding site SITE: 287-291 FOR-BINDING-OF: ubiquitin Ser phosphorylation site {S358} Ser phosphorylation site {S361}

Database Correlations

OMIM 601648 UniProt P55036 Pfam PF02809 Kegg hsa:5710

References

UniProt :accession P55036
OMIM :accession 601648

Component-of

19S proteasome (PA700 complex)