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disks large homolog 2; postsynaptic density protein PSD-93; channel-associated protein of synapse-110; chapsyn-110 (DLG2)
Function:
- required for perception of chronic pain through NMDA receptor signaling
- regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord
- interacts with
a) cytoplasmic tail of NMDA receptor subunits
b) inward rectifying K+ channels
- role in synaptic stability at cholinergic synapses
- component of postsynaptic protein scaffold of excitatory synapses (putative)
- palmitoylation of isoform 1 is not required for targeting to postsynaptic density (putative)
- interacts through its PDZ domains with NETO1
- interacts with NOS1/nNOS through second PDZ domain (putative)
- interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains
- interacts with FRMPD4 (via C-terminus)
Structure:
- isoform 2 has an L27 domain close to N-terminus
- belongs to the MAGUK family
- contains 1 guanylate kinase-like domain
- contains 3 PDZ domain (DHR domain)s
- contains 1 SH3 domain
Compartment:
- membrane, lipid-anchor (putative)
- cell junction
- synapse, postsynaptic cell membrane, postsynaptic density (putative)
- concentrated in soma & postsynaptic density of a subset of neurons (putative)
Alternative splicing: named isoforms=4
Related
discs large homolog
disks large-associated protein 1; DAP-1; guanylate kinase-associated protein; hGKAP; SAP90/PSD-95-associated protein 1; SAPAP1; PSD-95/SAP90-binding protein 1 (DLGAP1 DAP1 GKAP)
drosophila discs large [dlg] protein
General
phosphoprotein
scaffold protein
Properties
SIZE: entity length = 870 aa
MW = 98 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: cysteine residue {C5}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C7}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {S28}
Tyr phosphorylation site {Y58}
Ser phosphorylation site {S62}
PDZ domain
NAME: PDZ domain
SITE: 98-184
MOTIF: Ser phosphorylation site {S175}
PDZ domain
NAME: PDZ domain
SITE: 193-279
Tyr phosphorylation site {Y340}
Tyr phosphorylation site {Y348}
Ser phosphorylation site {S365}
Ser phosphorylation site {S406}
Ser phosphorylation site {S414}
PDZ domain
NAME: PDZ domain
SITE: 421-501
MOTIF: Tyr phosphorylation site {Y500}
Tyr phosphorylation site {Y505}
src homology 3 [SH3] domain
SITE: 536-606
domain {680-855}
MOTIF: Tyr phosphorylation site {Y750}
Tyr phosphorylation site {Y755}
HOMOLOGY: guanylate kinase
Database Correlations
OMIM 603583
UniProt Q15700
PFAM correlations
Entrez Gene 1740
Kegg hsa:1740
References
- UniProt :accession Q15700
- Lim IA, Hall DD, Hell JW.
Selectivity and promiscuity of the first and second PDZ
domains of PSD-95 and synapse-associated protein 102.
J Biol Chem. 2002 Jun 14;277(24):21697-711. Epub 2002 Apr 5.
PMID: 11937501