proline-rich protein 5 selections

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proline-rich protein 5 (PRR5)

Function: - role in regulation of PDGFRB expression & in modulation of PDGF signaling - may act as a tumor suppressor in breast cancer - component of the TORC2 complex - binds directly to FRAP1 & RICTOR within the TORC2 complex Alternative splicing: named isoforms=4 Expression: - most abundant in kidney & liver - also highly expressed in brain, spleen, testis & placenta Pathology: - overexpressed in several colorectal tumors

submaxillary gland androgen-regulated protein 3 homolog A; proline-rich protein 5; proline-rich protein PBI (SMR3A, PBI, PROL5)

General

proline-rich protein

Properties

SIZE: entity length = 388 aa MW = 43 kD MOTIF: RICTOR interaction {10-95} MOTIF: alanine-rich region {24-27} MOTIF: alanine residue (SEVERAL) proline-rich region RICTOR interaction {188-218}

Database Correlations

UniProt P85299

References

UniProt :accession P85299

Component-of

target of rapamycin 2 complex (TORC2 complex)

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