pre-mRNA-processing factor 40 homolog A (formin-binding protein 3, formin-binding protein 11, huntingtin-interacting protein HYPA, huntingtin yeast partner A, Fas ligand-associated factor 1, NY-REN-6 antigen, PRPF40A, FBP11, FLAF1, FNBP3, HYPA, HSPC225)

Function: 1) binds to WASL/N-WASP & suppresses its translocation from nucleus to cytoplasm, thus inhibiting its cytoplasmic function 2) role in pre-mRNA splicing (putative) 3) interacts with N-terminus of huntingtin 4) interacts with phosphorylated carboxyterminal domain of POLR2A 5) interacts with SF1, SRPK1 CARD8, ATBF1 & MECP2 6) interacts through the WW domains with formin proline-rich regions & with WASL/N-WASP Structure: - contains 5 FF domains - contains 2 WW domains WW domains are essential for localization to nuclear speckles Compartment: nucleus, nuclear speckle Alternative splicing: named isoforms=4 Expression: widely expressed

General

formin binding protein phosphoprotein

Properties

SIZE: MW = 109 kD entity length = 957 aa COMPARTMENT: cell nucleus MOTIF: WW domain (W/rsp5/WWP domain) {140-173} WW domain (W/rsp5/WWP domain) {181-214} FF domain {393-447} FF domain {460-519} FF domain {527-587} FF domain {607-667} FF domain {743-799} Ser phosphorylation site {S888} Ser phosphorylation site {S938}

Database Correlations

UniProt O75400 PFAM correlations

References

UniProt :accession O75400