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pantoprazole (Protonix)
Tradename: Protonix.
Indications:
- short-term erosive esophagitis associated with GERD
- pyrosis
- peptic ulcer disease
- effective when used in combination therapy for H pylori
- prevention of upper GI bleed associated with gastric acidity
- Zollinger-Ellison syndrome [3]
Dosage:
1) 40 mg PO QD-BID (40 mg equivalent to 20 mg of omeprazole)
2) 40 mg IV QD
Tabs: 40 mg enteric-coated tablets.
Injection: (Protonix IV)
Dosage adjustment for renal insufficiency: none*
* has been associated with tubulointerstitial nephritis [4]
Pharmacokinetics:
1) completely absorbed with or without food
2) bioavailability is 77%
3) 98% plasma protein bound
4) metabolized by cyt P450 system in the liver
5) metabolites excreted in the urine
6) elimination 1/2life is 1 hour
Adverse effects:
- uncommon (< 2%)
- headache (1.3%)
- diarrhea (1.5%)
- dizziness
- pruritus
- asthenia
- tubulointerstitial nephritis [4]
Drug interactions: none known
Mechanism of action:
1) proton pump inhibitor
2) interacts with sulfhydryl groups in proton pump
3) inactive at neutral pH
Notes: Manufacturer: Wyeth-Ayerst
Interactions
drug interactions
drug adverse effects of proton pump inhibitors (PPI)
General
proton pump inhibitor
pyrrole
Properties
INHIBITS: H+/K+ ATPase
MISC-INFO: elimination route LIVER
protein-binding 98%
1/2life 1 HOUR
Database Correlations
PUBCHEM cid=4679
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 2000
- Drugdex Drug Evaluuation 2000
- Deprecated Reference
- Medical Knowledge Self Assessment Program (MKSAP) 20
American College of Physicians, Philadelphia 2025