protein Tat (transactivating regulatory protein)

Function: 1) transcriptional regulator 2) binds to trans-activating responsive sequence (TAR) RNA element 3) activates transcription initiation &/or elongation from LTR promoter Compartment: nucleus, nucleolus Pathology: - interaction of extracellular viral Tat protein with FLK1 seems to enhance angiogenesis in Kaposi's sarcoma lesions - in HIV-1 infection, EP300, PCAF & GCN5L2 are recruited by the viral protein Tat; EP300, PCAF & GCN5L2 regulate Tat's transactivating activity & may help induce chromatin remodeling of proviral genes

Properties

SIZE: MW = 11 kD entity length = 101 aa

Database Correlations

SWISS-PROT correlations Pfam PF00539

References

UniProt :accession O12161