protein synthesis termination

Biochemistry: * see figure 1 - protein synthesis 17 - substrate: eukaryotic release factor + 80S-termination complex :p-site transfer RNA :amino-acyl peptide :product 80S-elongation complex (GDP, RNA-binding motif - UAG) :a-site eukaryotic release factor (peptidyl transferase) :p-site transfer RNA :amino-acyl protein * see figure 2 - protein synthesis 18 - enzyme: peptidyl transferase - substrate: 80S-termination complex :a-site eukaryotic release factor (peptidyl transferase, GDP, RNA-binding motif - UAG) :p-site transfer RNA :amino-acyl protein :product 80S-termination complex :a-site eukaryotic release factor (peptidyl transferase, GTP, RNA-binding motif - UAG) :p-site transfer RNA :amino-acyl unbound + protein * see figure 3 - protein synthesis 19 - substrate: 80S-termination complex :a-site eukaryotic release factor (peptidyl transferase, GTP, RNA-binding motif - UAG) :p-site transfer RNA :amino-acyl unbound :product 60S-ribosomal subunit + 40S-ribosomal subunit) + messenger RNA + CAP-binding protein + + transfer RNA :amino-acyl unbound + eukaryotic release factor (GDP) + H2PO4-

Properties

EVENTS: binding SUBSTRATE: eukaryotic release factor COMPARTMENT: cytoplasm CELL: most cell types* ORGANISM: eukaryote* MOTIF: guanine nucleotide-binding site EFFECTOR-BOUND: guanosine triphosphate binding site FOR-BINDING-OF: peptidyl transferase RNA-binding motif FOR-BINDING-OF: ribonucleic acid 80S termination complex COMPARTMENT: cytoplasm MOTIF: active site allosteric site P-SITE: transfer RNA MOTIF: anticodon loop AMINO-ACYL: peptide A-SITE: eukaryotic release factor MOTIF: guanine nucleotide-binding site EFFECTOR-BOUND: guanosine triphosphate binding site EFFECTOR-BOUND: peptidyl transferase RNA-binding motif EFFECTOR-BOUND: termination codon PRODUCT: 80S elongation complex COMPARTMENT: cytoplasm MOTIF: active site allosteric site P-SITE: transfer RNA MOTIF: anticodon loop AMINO-ACYL: protein A-SITE: eukaryotic release factor MOTIF: guanine nucleotide-binding site EFFECTOR-BOUND: guanosine triphosphate binding site EFFECTOR-BOUND: peptidyl transferase RNA-binding motif EFFECTOR-BOUND: termination codon TAG: PROTEIN-SYNTHESIS-17 enzymatic reaction ENZYME: peptidyl transferase COMPARTMENT: cytoplasm CELL: most cell types* ORGANISM: eukaryote* MOTIF: active site SUBSTRATE: 80S termination complex COMPARTMENT: cytoplasm MOTIF: active site allosteric site P-SITE: transfer RNA MOTIF: anticodon loop AMINO-ACYL: protein A-SITE: eukaryotic release factor MOTIF: guanine nucleotide-binding site EFFECTOR-BOUND: guanosine triphosphate binding site EFFECTOR-BOUND: peptidyl transferase RNA-binding motif EFFECTOR-BOUND: termination codon PRODUCT: 80S termination complex COMPARTMENT: cytoplasm MOTIF: active site allosteric site P-SITE: transfer RNA MOTIF: anticodon loop A-SITE: eukaryotic release factor MOTIF: guanine nucleotide-binding site EFFECTOR-BOUND: guanosine triphosphate binding site EFFECTOR-BOUND: peptidyl transferase RNA-binding motif EFFECTOR-BOUND: termination codon protein TAG: PROTEIN-SYNTHESIS-18 chemical reaction SUBSTRATE: 80S termination complex COMPARTMENT: cytoplasm MOTIF: active site allosteric site P-SITE: transfer RNA MOTIF: anticodon loop A-SITE: eukaryotic release factor MOTIF: guanine nucleotide-binding site EFFECTOR-BOUND: guanosine triphosphate binding site EFFECTOR-BOUND: peptidyl transferase RNA-binding motif EFFECTOR-BOUND: termination codon PRODUCT: 60S ribosomal subunit COMPARTMENT: cytoplasm 40S ribosomal subunit COMPARTMENT: cytoplasm messenger RNA TEMPLATE-FOR: protein eukaryotic initiation factor-4E COMPARTMENT: cytoplasm CELL: most cell types* ORGANISM: eukaryote* MOTIF: RNA-binding motif FOR-BINDING-OF: inverted GTP 5' cap structure transfer RNA COMPARTMENT: cytoplasm MOTIF: anticodon loop eukaryotic release factor COMPARTMENT: cytoplasm CELL: most cell types* ORGANISM: eukaryote* MOTIF: guanine nucleotide-binding site EFFECTOR-BOUND: guanosine triphosphate binding site FOR-BINDING-OF: peptidyl transferase RNA-binding motif FOR-BINDING-OF: ribonucleic acid guanine nucleotide-binding site EFFECTOR-BOUND: guanosine diphosphate H2PO4- TAG: PROTEIN-SYNTHESIS-19