protein N-terminal asparagine amidohydrolase; protein NH2-terminal asparagine amidohydrolase; PNAA; protein NH2-terminal asparagine deamidase; PNAD; protein N-terminal Asn amidase; protein NTN-amidase (NTAN1)

Function: 1) side-chain deamidation of N-terminal Asn to Asp 2) ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn a) these proteins are acetylated on the retained initiator Met & can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH) b) conversion of the resulting N-terminal Asn to Asp by PNAD renders the protein susceptible to arginylation, polyubiquitination & degradation as specified by the N-end rule 3) does NOT act on substrates with internal or C-terminal Asn 4) does NOT act on Gln residues in any position Structure: monomer Compartment: cytoplasm (putative)

Properties

SIZE: entity length = 310 aa MW = 35 kD COMPARTMENT: cytoplasm MOTIF: active site

Database Correlations

UniProt Q96AB6 Entrez Gene 123803 Kegg hsa:123803

References

UniProt :accession Q96AB6