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protein kinase G (PKG)

Pathology: - a human-like PKG is acquired by pathogenic forms of Mycobacteriumtuberculosis, which renders the bacteria resistant to bactericidal activity of macrophages, probably by inhibiting fusion of phagosomes with lysosomes

Interactions

molecular events

Related

tuberculosis

Specific

protein kinase G type-1; cGMP-dependent protein kinase type-1; cGMP-dependent protein kinase alpha (PRKG1, PRKGR1A, PRKG1B, PRKGR1B) protein kinase G type-2 (PRKG2, cGMP-dependent protein kinase type-2, PRKG2, CGK 2, cGKII)

General

serine/threonine kinase

Properties

STATE: active state MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site cGMP-binding site

References

  1. Lincoln TM, Cornwell TL. Intracellular cyclic GMP receptor proteins. FASEB J. 1993 Feb 1;7(2):328-38. Review. PMID: 7680013
  2. Journal Watch 24(13):107, 2004 Walburger A, Koul A, Ferrari G, Nguyen L, Prescianotto-Baschong C, Huygen K, Klebl B, Thompson C, Bacher G, Pieters J. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4. Epub 2004 May 20. PMID: 15155913