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protein kinase A2 [PKA2] regulatory subunit; AKAP5; A-kinase anchor protein 79; AKAP-79 (PKA2R)
Function:
1) PKA2 regulatory chains mediate membrane association by binding to anchoring proteins, including MAP2 kinase.
2) inactive form of PKA2 consists of 2 PKA2 regulatory chains & 2 cAMP protein kinase (catalytic) chains
3) activation by cAMP produces two active cAMP protein kinase monomers and a PKA2 regulatory chain dimer that binds 4 cAMP
4) interacts with AKAP4
5) phosphorylated by activated cAMP protein kinase
Compartment:
- may be bound to endomembranes.
Specific
protein kinase A2 [PKA2] regulatory subunit-alpha (PRKAR2A)
protein kinase A2 [PKA2] regulatory subunit-beta (PRKAR2B)
General
calmodulin binding protein
PEST protein
protein kinase A [PKA] regulatory subunit
Properties
SIZE: MW = 54 kD
COMPARTMENT: cytoplasm
MOTIF: PEST region
cAMP-binding site (2)
EFFECTOR-BOUND: cyclic AMP
calmodulin binding site
FOR-BINDING-OF: calmodulin
Database Correlations
OMIM 176910
UniProt P24588
References
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- Nigg EA, Baeuerle PA, Luhrmann R.
Nuclear import-export: in search of signals and mechanisms.
Cell. 1991 Jul 12;66(1):15-22. Review. No abstract available.
PMID: 1712670
Component-of
protein kinase A2