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annexin A6 (ANXA6, lipocortin-6, chromobindin-20, p67 calelectrin, calphobindin-2)
Function:
- may associate with CD21
- may regulate release of Ca+2 from intracellular stores
- phosphorylated in response to growth factor stimulation
- seems to bind one Ca+2 with high affinity
Structure:
- a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
- belongs to the annexin family
- contains 8 annexin repeats
Compartment:
- cytoplasm (putative), melanosome
- identified by mass spectrometry in melanosome fractions from stage 1 to stage 4
Expression: induced by EBV
General
annexin
lipocortin or calpactin
Properties
COMPARTMENT: cytoplasm
SIZE: entity length = 673 aa
MW = 76 kD
MOTIF: Annexin {29-89}
MOTIF: Tyr phosphorylation site {Y30}
Annexin {101-161}
Annexin {185-245}
MOTIF: Tyr phosphorylation site {Y201}
Annexin {260-320}
Annexin {372-432}
Annexin {444-504}
Annexin {533-593}
Annexin {608-668}
Database Correlations
OMIM 114070
UniProt P08133
Pfam PF00191
Entrez Gene 309
Kegg hsa:309
References
- OMIM :accession 114070
- UniProt :accession P08133