prostaglandin

Naturally-occuring prostaglandins include: - PGE1 - PGF1-alpha - PGF2 - FGF2-alpha - PGG2 - PGH2 - PGI2 - thromboxane A2 - thromboxane B2 - PGA1 - PGA2 - 19-alpha-OHPGA1 - 19-alpha-OHPGA2 - PGB1 - PGB2 - 19-alpha-OHPGB2 - PFB3 - PGF3-alpha Function: - diverse functions depending upon tissue - alters blood pressure in arterial smooth muscle - induces labor in uterine muscle - increases motility in lower GI tract - induces bronchial contraction & bronchospasm in bronchial smooth muscle - increases coagulability in platelets - increases permeability in capillaries - increases gastric acid secretion in stomach - inhibits triglyceride hydrolysis in adipose tissue Expression: - synthesized at the site of action - made in nearly all tissues - half life in seconds

Related

cyclooxygenase cascade prostaglandin in body fluid prostaglandin receptor resolvin

Specific

prostaglandin A prostaglandin B prostaglandin D prostaglandin E prostaglandin endoperoxide prostaglandin F prostaglandin I (prostacyclin, epoprostenol {Flolan}) prostaglandin J prostaglandin J2 thromboxane

General

fatty acid, unsaturated hormone

Properties

COMPARTMENT: membrane

References

Teitz Textbook of Clinical Chemistry and Molecular Diagnostics, 4th edition, Burtis CA, Ashwood ER, Burns DE (eds), Elsevier, St Louis, 2006