prostaglandin D2

PGD2 is the most abundant prostaglandin in brain. Function: - in the brain PGD2 a) regulates sleep - participates in the induction of non-REM sleep b) regulates temperature c) regulates nociception d) may have an anti-apoptotic role in oligodendrocytes - in peripheral tissues, PGD2 a) promotes vasodilatation b) promotes bronchoconstriction c) mediates allergic reactions d) inhibits platelet aggregation e) reduces intraocular pressure - PGD2 signals through 2 G protein-coupled receptors a) PTGDR1 (DP1) - linked to Gs b) CRTH2 (DP2) - linked to Gi * PGH2 is the initial product of COX activity. Pharmacokinetics: - PGD2 is formed from PGH2* by two distinct PGD synthases a) the lipocalin-type synthase (L-PGDS) b) the glutathione-dependent hematopoietic PGD synthase (H-PGDS) - PGD2 levels increase markedly with excess glutamate release (i.e. seizures, ischemia) via increased COX-2 activity - metabolized to 15dPDJ2

General

arachidonate; arachidonic acid [C20:4w6, ARA] prostaglandin D

Properties

SIZE: MW = 304.5 G/MOL COMPARTMENT: membrane

References

Liang X, Wu L, Hand T, Andreasson K. Prostaglandin D2 mediates neuronal protection via the DP1 receptor. J Neurochem. 2005 Feb;92(3):477-86. PMID: 15659218